Methanesulfonamide
【Chemical Name】 Methanesulfonamide
【Synonym】 Methylsulfonamid;METHYL SULFONYLAMINE;METHYL SULFONAMIDE;LABOTEST-BB LT00153664;Methanesulfonamide, 98+%;Methanesulphonamide,98+%;Mesyl amide;Methanesulfonyl amide
【CAS No】3144-09-0
【Molecular Formula】 CH5NO2S
【Molecular Weight】95.12
【Properties】 Melting point 85-89 ° C (lit.) Boiling point 208.2 ± 23.0 ° C (predicted) Density 1.229 (estimate) Refractive index 1.5130 (estimate)
【Packing】25kg/drum
【Usage】 Used for pharmaceutical intermediates and pesticide herbicides
【Introduction】
Methanesulfonamide, also known as methanesulfonamide or sulfonamide, is a compound widely used in drug synthesis. It is mainly used as a pharmaceutical intermediate and pesticide intermediate, especially in the production of agricultural herbicides. The following are some specific applications of methyl sulfonamide in drug synthesis:
1. Synthesis of Sulfonamide Drugs: Methanesulfonamide is an important component of sulfonamide drugs, which have a wide range of applications in medicine, including antibacterial, antifungal, antiparasitic, antioxidant, and anti-tumor properties.
2. * * Organic synthesis reactions * *: Methanesulfonamide can serve as a nitrogen source and participate in many organic synthesis reactions, such as amination, imidization, substitution reactions, etc.
3. * * Electrophilic reagent * *: Methanesulfonamide can also be used as a stable electrophilic reagent, participating in many addition reactions such as Michael addition, Diels Alder reaction, etc., and therefore has a wide range of applications in organic synthesis.
4. * * Pesticide Intermediates * *: methanesulfonamide is an intermediate of the herbicide fomesafen, which is used to produce farmland herbicides. It is a highly selective post seedling herbicide for soybean and peanut fields, which can effectively control broadleaf weeds and aconite in soybean and peanut fields, and has certain control effect on gramineous weeds.
5. Synthesis of Drug Molecules: Methanesulfonamide has certain applications in the synthesis and production of sulfonamide drug molecules, and can be used to synthesize various biologically active drug molecules.
6. * * Synthesis of anti-tumor drugs * *: Methylsulfonylamine is also used in the synthesis of certain anti-tumor drugs, such as in the synthesis of imatinib mesylate, which can serve as a key intermediate.
In summary, methyl sulfonamide plays an important role in drug synthesis, not only for the synthesis of sulfonamide drugs, but also as an intermediate and reagent in organic synthesis, participating in the synthesis of various drug molecules.